Biochemistry - MCQ Practice Questions

In the pentose phosphate pathway, which vitamin is required as a coenzyme for the oxidative phase?

Glycogen phosphorylase is activated during fight-or-flight response primarily through which mechanism?

In the glycolytic pathway, the enzyme that catalyzes substrate-level phosphorylation in the ATP-generating step is:

A patient with type 2 diabetes shows impaired glucose uptake in muscle tissue. Which GLUT isoform is primarily defective?

Which of the following statements about branching enzyme (α-1,6-glucosidase) is correct?

In the Rapoport-Luebering shunt of RBCs, 2,3-bisphosphoglycerate (2,3-BPG) is produced from which glycolytic intermediate?

During fasting state lasting 24-48 hours, which substrate becomes the predominant fuel source for the brain after glucose stores are depleted?

Which enzyme is inhibited by feedback inhibition from glucose-6-phosphate and is thus rate-limiting for glucose entry in liver?

In McArdle disease (GSD Type V), the enzyme deficient is glycogen phosphorylase. Which of the following is the most likely clinical presentation during exercise?

The oxidative phase of the pentose phosphate pathway produces NADPH. Which of the following is the primary biosynthetic use of NADPH?

Which statement best describes the relationship between glycogen structure and its metabolic advantages?

In the citric acid cycle, which carbohydrate-derived molecule enters directly after acetyl-CoA formation?

Which of the following conditions causes increased glycogenolysis in muscle tissue during exercise?

What is the primary fate of pyruvate under anaerobic conditions in muscle during intense exercise?

Which enzyme deficiency causes Pompe disease (GSD Type II)?

During the pentose phosphate pathway, which coenzyme is reduced to generate NADPH?

Which of the following best explains why glycogen is more soluble than starch despite similar glycosidic linkages?

In a patient with von Gierke disease, excessive hepatic glucose production is primarily due to:

Which of the following substrates can be directly utilized for glycogen synthesis in the liver?

A patient presents with inability to metabolize galactose. Which enzyme deficiency is most likely responsible for classical galactosemia?