Biochemistry - MCQ Practice Questions

What is the primary fate of pyruvate under anaerobic conditions in muscle during intense exercise?

Which enzyme deficiency causes Pompe disease (GSD Type II)?

During the pentose phosphate pathway, which coenzyme is reduced to generate NADPH?

Which of the following best explains why glycogen is more soluble than starch despite similar glycosidic linkages?

In a patient with von Gierke disease, excessive hepatic glucose production is primarily due to:

Which of the following substrates can be directly utilized for glycogen synthesis in the liver?

A patient presents with inability to metabolize galactose. Which enzyme deficiency is most likely responsible for classical galactosemia?

The branching enzyme in glycogen synthesis catalyzes which type of reaction?

During high-intensity exercise, which carbohydrate provides immediate energy despite low concentration in blood?

Which of the following is NOT a function of glycogen in liver?

A newborn presents with hepatomegaly, lactic acidosis, and hypoglycemia. Enzyme analysis shows deficiency of glucose-6-phosphatase. Which disease is this?

In hereditary fructose intolerance (HFI), which enzyme deficiency causes accumulation of fructose-1-phosphate?

In the pentose phosphate pathway, the oxidative phase generates NADPH. Which metabolic process primarily utilizes this NADPH in fed state?

The Haworth projection of glucose differs from its Fischer projection. Which structural feature is best represented in Haworth projection?

During fasting, which hormonal change directly increases hepatic glycogenolysis?

Which adaptation occurs in liver during prolonged fasting to maintain blood glucose?

A 45-year-old patient with Type 2 diabetes mellitus shows elevated fasting blood glucose (180 mg/dL) but normal HbA1c levels initially. Which carbohydrate metabolism pathway is primarily impaired in this patient's liver?

In the context of lipid metabolism, what does beta-oxidation primarily accomplish?

Which of the following is a consequence of excessive cholesterol accumulation in arteries?

A patient with familial hypercholesterolemia shows extremely high cholesterol levels. What is the most likely defect?